On sensitivity to antibacterial preparations of strains of Bacillus spp. with a high level of antagonistic activity for the production of probiotics

The development of organic livestock farming, in particular poultry which Ukraine is targeting, requires a radical change approaches to the prevention and treatment infectious diseases. macroorganism microbiota gastrointestinal tract constitute single ecological system with homeostatic balance. However, its violation creates threat an imbalance intestinal normal flora diseases bacterial etiology poultry. Considering this, there growing need for use probiotic preparations. high antagonistic potential bacteria genus Bacillus relation other pathogens causes scientific industrial interest probiotics their involvement composition these as alternative antibiotics. But due existence risks direct transfer R-plasmids antibiotic resistance biotic microflora together strains when they acquire resistance, promising should be tested sensitivity drugs. We selected level antagonism, subtilis Bs-5 Bs-9, licheniformis Bfl-1 Bfl-4, coagulans Bcg-5, amyloliquefaciens Baf-1 Baf-3 showed full applied antibiotics — representatives groups carbapenems, fluoroquinolones, glycopeptides, lincosamides, macroliths oxazolidones. These were recommended probiotic, sensitive, safe design obtained results laboratory studies B. subtilis, licheniformis, coagulans, proved presence among them polyresistant fluoroquinolone, carbapenem, macrolide glycopeptide